UFT: East meets West in drug development.

نویسنده

  • R Pazdur
چکیده

Although the combination of uracil and tegafur (UFT) has been available commercially in Japan since 1984 and is one of the most extensively prescribed antineoplastic agents in that country, few physicians outside Japan have knowledge of and experience with the drug. The development of UFT, which combines uracil and tegafur in a 4:1 molar concentration, dates back to the pioneering work of Fujii in the late 1970s and is based on the observation of uracil’s ability to inhibit the degradation of fluorouracil (5-FU) generated from tegafur.[1] This was an early example of biochemical modulation, with uracil inhibiting the enzyme dihydrouracil dehydrogenase and thus prolonging plasma 5-FU levels and increasing 5-FU distribution to tumors compared with normal tissues.[2]

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عنوان ژورنال:
  • Oncology

دوره 11 9 Suppl 10  شماره 

صفحات  -

تاریخ انتشار 1997