UFT: East meets West in drug development.
نویسنده
چکیده
Although the combination of uracil and tegafur (UFT) has been available commercially in Japan since 1984 and is one of the most extensively prescribed antineoplastic agents in that country, few physicians outside Japan have knowledge of and experience with the drug. The development of UFT, which combines uracil and tegafur in a 4:1 molar concentration, dates back to the pioneering work of Fujii in the late 1970s and is based on the observation of uracils ability to inhibit the degradation of fluorouracil (5-FU) generated from tegafur.[1] This was an early example of biochemical modulation, with uracil inhibiting the enzyme dihydrouracil dehydrogenase and thus prolonging plasma 5-FU levels and increasing 5-FU distribution to tumors compared with normal tissues.[2]
منابع مشابه
Short communication: Study on bioaccumulation of heavy metals (cadmium, nickel, zinc and lead) in the muscle of wels catfish (Silurus glanis) in the Anzali Wetland
Catfish of Anzali wetland has been focused economically and commercially. It also meets the religious Minorities needs to fish meat. So, investigation of its health in the wetland is important. This study aimed to investigate the concentration of heavy metals such as cadmium, Nickle, Zinc and lead in muscle tissues of Catfish in three stations (west, central and east) of Anzali wetland in 2012....
متن کاملSurvey on Perception of People Regarding Utilization of Computer Science & Information Technology in Manipulation of Big Data, Disease Detection & Drug Discovery
this research explores the manipulation of biomedical big data and diseases detection using automated computing mechanisms. As efficient and cost effective way to discover disease and drug is important for a society so computer aided automated system is a must. This paper aims to understand the importance of computer aided automated system among the people. The analysis result from collected da...
متن کاملThe Role of R&D in Trade Expansion: A Semi-parametric Gravity Specification for East and West Asia
In more recent years, it has become increasingly recognized that R&D (research and development) is a key driver of economic growth, a source of innovation and change, and as such stimulates improvements in productivity and economic competitiveness. It is closely associated with knowledge and flexibility, two factors that have gained new significance as a source of competitiveness in an increasi...
متن کاملEast meets West: current issues relevant to integrating Chinese medicine
This article describes the challenges that integration of Chinese medicine (CM) and biomedicine are likely to bring for improving safety, research, education, and cross-disciplinary communication. Potential strategies to meet these challenges are suggested, including the use of accessible language for the Western biomedical community, and further development of whole-system randomized controlle...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Oncology
دوره 11 9 Suppl 10 شماره
صفحات -
تاریخ انتشار 1997